Based on new data on seismicity and materials from surveys of active faults, information was obtained on regional seismogenic structures of the European-African through tectonic belt. The kinematic characteristics of the faults that make up the through tectonic belt and earthquakes that occurred within these structures are given. An analysis of gravity anomalies based on satellite data suggests that the seismogenic structures of the European -African through tectonic belt have an ultra-deep penetration into the mantle, which determines their high seismic potential.